发明名称 |
FOERFARANDE FOER FRAMSTAELLNING AV NAPROXEN. |
摘要 |
Process for preparing Naproxen via a sequence of stereospecific reactions which comprises: condensation of 1-chloro-2-methoxy-naphthalene with a (S)-2-halo-propionyl halide according to the Friedel-Crafts reaction, ketalization of the thus obtained (S)-2-halo-1-(5'-chloro-6'-methoxy-2'-naphthyl)-propan-1-one, rearrangement of said ketal to afford an ester, hydrolysis of the ester and removal of the chlorine atom in 5-position by hydrogenolysis. New (S) 2-halo-1-(5'-chloro-6'-methoxy-2'-naphthyl)-propan-1-ones. |
申请公布号 |
FI851847(L) |
申请公布日期 |
1985.11.11 |
申请号 |
FI19850001847 |
申请日期 |
1985.05.09 |
申请人 |
BLASCHIM S.P.A. |
发明人 |
PICCOLO, ORESTE;VALOTI, ERMANNO;VISENTIN, GIUSEPPINA |
分类号 |
C07C45/54;B01J23/00;B01J27/00;C07B61/00;C07C45/00;C07C45/46;C07C49/84;C07C51/00;C07C51/09;C07C51/377;C07C59/64;C07C67/00 |
主分类号 |
C07C45/54 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|