发明名称 PULVERIZED PULYVALENT METAL SALT OF 2-MERCAPTOPYRIDINE N-OXIDE, ITS PREPARATION AND ANTIBACTERIAL COMPOSITION CONTAINING THE SAME
摘要 PURPOSE:The titled metal salt which is used as antifungal and dandruff-removing agent is pluverized using a specific dispersant under specific conditions to improve the dipersion stability of the metal salt in the antifungal composition such as shampoo or rinse and the adsorption to skins and hairs. CONSTITUTION:A dispersion of a polyvalent metal salt of 2-mercapto-N-oxide is stirred together with solid media of less than 0.2mm. particles sizes in the presence of (meth)acrylic acid-styrenesulfonic acid copolymer of 10,000-1,000,000 average molecular weight as a dispersant to give fine particles of the above-mentioned metal salt containing more than 50wt% of particles of less than 0.1mu particle sizes, preferably containing less than 15wt% of particles of 0.2-0.5mu sizes and less than 5wt% of particles exceeding 0.5mu, thus being less than 0.5mu on the average. The resultant particles can be added to the above-cited antifungal composition with no use of a special polymer with high stability, further, the improvement in adsorption increases its activity of fungi control and dandruff removal.
申请公布号 JPS60224676(A) 申请公布日期 1985.11.09
申请号 JP19840082690 申请日期 1984.04.24
申请人 KAO SEKKEN KK 发明人 NOZAKI TOSHIO;IMAMURA TAKASHI;NISHINO KENJI;KANAI HIROYUKI
分类号 A61K8/00;A61K8/49;A61K31/44;A61K31/555;A61P31/04;A61Q5/00;A61Q5/02;A61Q7/00;C07D213/89;C07F3/06 主分类号 A61K8/00
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