| 摘要 |
PURPOSE:In pharmaceutical preparation of uricase containing uricase in a stable state, to obtain pharmaceutical preparation for diagnosis having high reliability, by adding a nonionic surface active agent, serum albumin and/or a basic amino acid to uricase. CONSTITUTION:Uricase is dissolved in a proper buffer solution to give a uricase solution, which is blended with a stabilizer consisting of a nonionic surface active agent, serum albumin and/or a basic amino acid. They are stirred by a conventional procedure, and the mixed solution is dried by lyophilization, spray drying, etc. to give a product. |
