| 摘要 |
<p>A cell system for the reproducible detection and isolation of human T-lymphotropic retroviruses (HTLV-family) with cytophatic effects (HTLV-III) from patients with the acquired immune deficiency syndrome (AIDS), pre-AIDS and healthy carriers. One neoplastic aneuploid T-cell line derived from an adult with lymphoid leukemia, termed HT, was susceptible to infection with HTLV-III, which is transformed and provides T-cell population which are highly susceptible to and permissive for HTLV-III, and convenient for large scale production, isolation, and biological detection of the virus. Other operational neoplastic T-cell lines which are positive for OKT4 marker, e.g., Molt 3, CEM, Ti7.4 and HUT78, can produce HTLV-III in a large amount and retain its unlimited capability for growth.</p> |
