发明名称 |
METHOD OF PRODUCING CEPHALOSPORIN DERIVATIVES OR SALTS THEREOF |
摘要 |
NEW MATERIAL:A compound shown by the formulaI(R<1> is H or carboxyl- protecting group; R<2> is aromatic hydrocarbon group, acylamino, etc.; R<3> is H or alkoxy; R<4> is H or halogen; R<5> is H or amino; A is -CH2-, etc.; Z is S,S O; one of dotted lines in the cephem ring is double bond) and its salt. EXAMPLE:7-[2-(2-Aminothiazole-4-yl)acetamido]-3-[2-(5-acetamido-1,2,3, 4-tetrazolyl) methyl]-DELTA<3>-cephem-4-carboxylic acid. USE:An antibacterial agent effective against Gram-positive and Gram-negative bacteria. Stable to beta-lactamse, having low toxicity. PROCESS:A compound shown by the formula II or its salt is reacted with an aromatic hydrocarbon, etc. in an organic solvent in the presence of an acid, etc., to give a compound shown by the formula III. This compound is reacted with a compound shown by the formula IV, to give shown by the formulaI. |
申请公布号 |
SU1190987(A3) |
申请公布日期 |
1985.11.07 |
申请号 |
SU19813340952 |
申请日期 |
1981.09.24 |
申请人 |
TOYAMA KEMIKL KOMPANI,óT¯ (´ôPMA) |
发明人 |
TATSUO KHIRAKAVA,JP;KHIDEO TAKI,JP;MAZARU TAI,JP;YASUO VATANABE,JP;ISAMU SAIKAVA,JP;KHIROSI SADAKI,JP;KHIROKAZU NARITA,JP;KHIROYUKI IMAIZUMI,JP;ESINORI KONISI,JP;TAKIKHIRO INABO,JP |
分类号 |
C07D501/20;A61K31/545;A61K31/546;A61P31/04;B65G65/46;C07D;C07D501/06;C07D501/24;C07D501/34;C07D501/38;C07D501/46;C07D501/60 |
主分类号 |
C07D501/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|