| 摘要 |
NEW MATERIAL:A compound shown by the formula I [R1 is H, or (OH-substituted)1-6C alkyl; R2 is group shown by the formula II or III (Q is single bond, chain 1-6C alkylene; m is 3-6; n is 1-4; R4-R6 are H, 1-6C alkyl); R3 is H, or ester residue]. EXAMPLE:( 5R,6S,8R )-2-( 1-Carbamimidoylpyrrolidin-3-ylthio )-6-( hydroxyethyl ) penem-3-carboxylic acid. USE:An antibacterial agent. Having improved antibacterial power and stability, obtainable in high yield. PREPARATION:For example, a compound [e.g., p-nitrobenzyl(5R,6S,8R)-2-ethylsulfinyl-6-(1-hydroxyethyl)penem-3-carb oxylate, etc.] shown by the formula IV(R7 is organic group) is reacted with a compound (e.g., 3-mercapto-1-p-nitrobenzoyloxycarbamimidoylpyrrolidin, etc.) shown by the formula R8SH [R8 is (protected) R2; different from R7], and deprotected, to give a compound shown by the formula I. |
