PREPARATION OF NITROARYLACETIC ACID ESTERS AND DERIVATIVES THEREOF

摘要

Nitroarylacetic acid esters may be prepared by reacting a nitroaromatic compound with an alpha-substituted monocarboxylic acid ester, e.g. an alphas, alpha-disubstituted acetic acid ester, in a substantially anhydrous aprotic solvent and in the presence of a base so that the ester undergoes a nucleophilic substitution on an unsubstituted ring carbon of the nitroaromatic compound during which an alpha-substituent functions as a leaving group. The nitroarylacetic acid esters formed by the process can be readily converted into derivatives, such as pharmaceuticals.