发明名称 |
Guanine-N7-oxide |
摘要 |
A purified isolate of an actinomycete identified as ATCC 39364 is capable of producing the antimicrobial/antitumor compound 2-amino-1,9-dihydro-6H-purine-6-one-7-oxide, commonly known as guanine-N7-oxide. Guanine-N7-oxide is produced by cultivating isolate ATCC 39364 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of the compound is produced and thereafter isolating the compound. The antibiotic/antitumor compound guanine-N7-oxide and pharmaceutical compositions comprising this compound or one of its pharmaceutically acceptable salts together with a pharmaceutically acceptable carrier are also disclosed as is a method of treating microbial infections in a mammal or of treating tumors in a mammal.
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申请公布号 |
US4551529(A) |
申请公布日期 |
1985.11.05 |
申请号 |
US19830539517 |
申请日期 |
1983.10.06 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
KERN, DONALD L.;HOKANSON, GERARD C.;FRENCH, JAMES C. |
分类号 |
A61K31/52;A61K31/522;A61P31/04;A61P35/00;C07D473/18;C12P17/18;C12R1/01;(IPC1-7):C07D473/18;C12R1/04 |
主分类号 |
A61K31/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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