DNA OF NOVEL PHYSIOLOGICALLY ACTIVE POLYPEPTIDE

摘要

PURPOSE:The TNF gene having the amino acid sequence of formula and capable of producing a physiologically active proteinous substance having carcinostatic activity. CONSTITUTION:The cell capable of producing L-cell cytotoxicity by the stimulation of bacterial endotoxin is collected from a rabbit administered with a substance having reticuloendothelial system-activating activity. The objective TNF (Tumor Necrosis Factor) gene can be separated from the L-cell cytotoxicity-producing cell by a genetic engineering technique.