| 摘要 |
Carboxamide derivs. of formula(I) and their salts are prepd. by reacting II with R2-N=C=O or III with R1-C(=O)-OH in an inactive solvent. In (I), X=H, F, Cl, Br, alkyl, alkoxy, alkylthio, CF3, PhCONH or di-(C1-3) alkylsulphamoyl; Y=H, F, Cl, Br, C1-4 alkylthio or CF3; or X+Y=4,5-, 5,6- or 6,7-OCH2O or -OCH2CH2O-; R1=alkyl, cycloalkenyl, opt. substd. Ph, or (CH2)n-QR; Q=divalent radical derived from furan, thiophene, oxazole or benzo(b)thiophene; n=0,1 or 2; R=H or C1-3alkyl; R2=alkyl or alkoxy. (I) are inhibitors of cyclo- oxygenase and lipoxygenase enzymes. They have analgesic and anti- inflammatory activities and are esp. suitable for treating acute pain and for chronic admin. in treatment of arthritis. |
