| 摘要 |
<p>The invention relates to new conjugates of vinblastine and some of its known derivatives with proteins, fragments thereof, aminoacids or amines, which are useful as anti-tumor agents. The invention also relates to some intermediates which are active in chemotherapy, and amino derivatives thereof. These compounds correspond to the following general formula <IMAGE> in which A represents an acetylamino-, trifluoroacetylamino- or carbobenzyloxyamino- substituted -CO(CH2)nCO- or <IMAGE> in which n is 1 to 5, R1 represents an optionally modified protein radical, R2 represents a methoxy group, an amino group or an alpha-aminoacid ester radical which is bonded via a bond of the amide type and in which the ester group contains 1 to 6 carbon atoms, and R3 represents hydrogen or hydroxyl.</p> |
