| 摘要 |
<p>This invention relates to 1,3-dihydro-6-methyl-7-hydroxy-furo-(3,4-c)-pyridine derivatives of the general formula I <IMAGE> I wherein each of A1 and A2 independently represents various hydrocarbon groups and therapeutically acceptable addition salts thereof; to a process for the preparation of the same comprising oxidizing the secondary alchol alpha 4, 3-o-isopropylidene-1-methyl-5-(1-hydroxy-1-A1)-methyl pyridine by any usual technique, reacting the resultant ketone with a compound of the general formula XA2 wherein X stands for Br or I in the presence of magnesium in diethyl ether at the boil and treating the resultant tertiary alcohol with an acidic agent to provoke breaking of the isopropylidene ring and 3,4-cyclization; and to pharmaceutical compositions containing these derivatives.</p> |
