AN OCCLUSION COMPOUND OF 2-NITROXYMETHYL-6-CHLOROPYRIDINE WITH BETA-CYCLODEXTRIN AND PROCESS FOR PREPARATION THEREOF

摘要

An occlusion compound of 2-nitroxymethyl-6-chloropyridine with beta -cyclodextrin is disclosed herein as well as a process for preparing the occlusion compound thereof. The occlusion compound of the present invention has a molar ratio of 2-nitroxymethyl-6-chloropyridine to beta -cyclodextrin of between about 1:1 and about 3:1. The present occlusion compound is nonvolatile, thereby overcoming the problems associated with the volatility of the 2-nitroxymethyl-6-chloropyridine for pharmacuetical preparations. The process of the present invention is carried out by reacting 2-nitroxymethyl-6-chloropyridine with beta -cyclodextrin either by kneading both compounds together with a small amount of a solvent or by mixing both compounds in an appropriate solvent, such as water. The occlusion compound is then precipitated, separated and further purified by conventional methods.