(3-AND/OR 4)-(DI-OR MONOMETHYL)-5-(PYRIDINYL OR HYDROXYPHENYL)-2(1H)-PYRIDINONES, THEIR PREPARATION AND THEIR CARDIOTONIC USE

摘要

3-R1-4-R2-5-Q-6-R-2(1H)-pyridinones (I), where R1 and R2 are each hydrogen or methyl, R is lower-alkyl, and Q is 4(or 3)-hydroxyphenyl, 4(or 3)-methoxyphenyl, 4(or 3)-pyridinyl or 4(or 3)-pyridinyl having one or two lower-alkyl substituents, or acid-addition salts thereof when Q is a pyridinyl substituent, and their preparation are shown. Also shown and claimed is the cardiotonic use of I where Q is 4(or 3)-hydroxyphenyl, 4(or 3) -pyridinyl or 4(or 3)-pyridinyl having one or two lower-alkyl substituents, and at least one of R1 and R2 is methyl.