| 摘要 |
PURPOSE:To obtain the titled compound having high purity and useful as a synthetic intermediate of pharmaceuticals, in two steps, from m-hydroxybenzoic acid available industrially at a low cost, by carrying out the double alkylation with an alkylation agent, and reducing the product. CONSTITUTION:m-Hydroxybenzoic acid is made to react with an alkylation agent preferably dimethyl sulfate, etc. in an inert solvent, preferably dioxane, etc., in the presence of an alkaline substance such as NaOH, to effect the double alkylation of OH and carboxyl group at the same time. After the completion of the reaction, the obtained m-alkoxybenzoic acid alkyl ester is separated by extraction, etc., and purified and recovered by distillation. The product is reduced e.g. by hydrogenation with molecular hydrogen at 120-220 deg.C and 50-300kg/ cm<2> pressure. The objective m-alkoxybenzyl alcohol can be recovered easily in high purity by the simple distillation of the reduction product. |
