NEUE 9-HALOGEN-PROSTAGLANDINE

摘要

9-halogen-prostane having the formula (I) wherein Hal represents a chlorine or fluorine atom in position alpha or beta ; R1 represents the rest CH2OH or the formula (A) with R2 representing a hydrogen atom, an alkyl, cycloalkyl, aryl or heterocyclic rest or R1 represents the rest of formula (B) with R3 representing an acid rest or the rest R2; A is a group -CH2-CH2-, -CH=CH- trans or -C=C-; W is free or functionally transformed hydroxy methylene group or a free or functionally transformed group having the formula (C), the group OH susceptible of being in position alpha or beta ; D and E represent together a direct bound or D represents a straight branched or cyclic chain alkylene group with 1 to 10 atoms of carbon, substituted optionally by fluorine atoms, and E represents oxygen or sulfur, a direction bound, a bound -C=C- or a group -CR6=CR7, R6 and R7 being different and representing hydrogen, chlorine or alkyl with 1 to 4 atoms of carbon; R4 is a free or functionally modified hydroxy group; R5 is a hydrogen atom, an alkyl, a halogen-substituted alkyl, a cycloalkyl, an optionally substituted aryl or a heterocyclic group; as well as, if R2 represents a hydrogen atom, the salts thereof with physiologically acceptable bases, the preparation process thereof and the pharmaceutical utilization thereof.