Process for the preparation of 21-hydroxy-20-keto- DELTA 16-steroids and new intermediate compounds formed in this process

摘要

A novel process for the preparation of 21-hydroxy-20-keto- DELTA 16-steroids comprising reacting a 17-(isocyanosulfonylmethylene)-steroid with an aldehyde and an alcohol to form a 17-(2-alkoxy-3-oxazolin-4-yl)- DELTA 16-steroid and subjecting the latter to hydrolysis to obtain the corresponding 21-hydroxy-20-keto- DELTA 16-steroid which are useful to prepare corticoid steroids and novel intermediates.