PROCEDIMIENTO PARA LA OBTENCION DEL ESTER BENZOILMETILICO DEL ACIDO 1-ETIL-6-FLUORO-7-(1-PIPERACINIL)-4-OXO-1,4-DIHIDRO-QUINOLIN-3-CARBOXILICO

摘要

Norfloxacine benzoyloxy methyl ester (I) is new. (I) is prepd. by a three-stage synthesis as follows: the fluoro chloro dihydroquinoline carboxylic acid (II) is treated with N-trityl piperazine (III) in the presence of acid acceptors, and the prod. treated with KOH. The K salt of the resultant acid is esterified with chloromethyl benzoate (V) and the protecting trityl gp. is removed.