发明名称 |
PROCESS FOR MANUFACTURING LOW MOLECULAR WEIGHT HEPARINS BY DEPOLYMERIZATION OF NORMAL HEPARIN |
摘要 |
<p>PROCESS FOR MANUFACTURING LOW MOLECULAR WEIGHT HEPARINS BY DEPOLYMERIZATION OF NORMAL HEPARIN Process for manufacturing low molecular weight heparin fractions from normal heparin wherein such fractions have better pharmacological and therapeutic properties than the normal heparin. The process comprises the steps of, (a) acififying normal heparin to obtain heparinic acid with a pH in the range of about 3 to about 5, and (b) depolymerizing the heparinic acid by heating in the presence of an oxidizing agent to obtain low molecular weight heparin fractions in the range of about 4,000 Dalton to about 12,000 Dalton.</p> |
申请公布号 |
CA1195322(A) |
申请公布日期 |
1985.10.15 |
申请号 |
CA19820418428 |
申请日期 |
1982.12.23 |
申请人 |
HEPAR INDUSTRIES, INC. |
发明人 |
SMITH, MILTON R.;AMAYA, EDUARDO;FUSSI, FERNANDO |
分类号 |
C08B37/10;A61K31/715;A61P7/02;C08B37/00;(IPC1-7):C08B37/10 |
主分类号 |
C08B37/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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