摘要 |
This invention relates to an improved anti-ulcer composition for prophylaxis and treatment of stomach and duodenum ulcers, including stress ulcers. The composition provides potent anti-ulcer activity with a dramatic reduction in toxicity and harmful side effects. The composition comprises a histamine H2 antagonist based on a guanidine derivative, preferably [N-cyano-H'-methyl-N'']-2(4-methyl-imidazolyl)-methylthio-[ethylguanid ine]; and at least one 4-phenyl-tetrahydroisoquinoline antidepressant, preferably the [+] isomer of 4-phenyl-2-methyl-8-amino-1,2,3,4-tetrahydroisoquinoline hydrogen maleate. The composition may also contain a spasmolytic agent, preferably 2-metoxycarbonyl-4-(beta-piperidino ethyl) -metoxycarbonyl-4-(beta-peperidinoethyl) benzophenone. The ratio of antagonist to antidepressant ranges from 2:1 to 60:1, and the ratio of their sum to the spasmolytic agent, when used, ranges from 2.2:1 to 42.5:1. |
申请人 |
T P O PHARMACHIM |
发明人 |
IVANOVA, NEDYALKA STOYANOVA;IVANOV, TSHAVDAR BORISSOV;DRYANSKA, MARGARITA DIMITROVA;ZABUNOVA, ORHIDEYA BONTSHEVA;DALLEVA, LILYANA DIMITROVA;NIKOLOVA, MILKA PETROVA;BEROVA, NIKOLINA DIMITROVA;RAKOVSKA, ROSSITZA STEFANOVA;STOYANOVA, MARIA STOYANOVA;MIHAYLOVA, SASCHA RADKOVA;LUNA, MILKA ARON;NISSIMOV, JOSSIF NISSIM;VITKOVA, SNEJANA GEORGIEVA;MATOV, VLADIMIR KONSTANTINOV;DIMITROV, BORIS KRUMOV;METSHKOV, GRIGOR MINTSHEV |