BENZOFURAN DERIVATIVE, ITS PREPARATION, AND HYPOTENSIVE AGENT CONTAINING SAID DERIVATIVE AS ACTIVE COMPONENT

摘要

NEW MATERIAL:The compound of formula I (X is acetyl, carbamoyl, cyano, lower alkoxycarbonyl, etc.; R is H, lower alkoxy, lower alkyl or halogen; R is substituted at the o-, m- or p-site to piperazinyl ring; the group of formula II is substituted at 4-7 site of the benzofuran ring). EXAMPLE:2-Acetyl-7-[3-(4-phenylpiperazinyl)-2-hydroxypropoxy]benzofuran. USE:A hypotensor. It has excellent alpha-adrenaline blocking activity and Ca antagonistic activity, and low side effect. PREPARATION:The compound of formula I can be prepared by reacting the 2,3- epoxypropoxybenzofuran derivative of formula III with the N-phenylpiperazine derivative of formula IV in the presence of a base such as NaOH, in a solvent such as methanol, at room temperature -100 deg.C for 15min-10hr.