发明名称 2,4-DIOXA-6,8-DITHIABICYCLO(3,3,0)OCTANE DERIVATIVE, ITS PREPARATION, AND ITS USE
摘要 NEW MATERIAL:A compound shown by the formula I [R<1> is H, its salt-forming residue, alkyl, or alkenyl; R<2> is COOH, its salt-forming salt, alkyloxycarbonyl, alkylcarbonyl, etc.; R<3> is alkyl(oxy), cycloalkyl, or (substituted)phenyl; R<4> is H, or alkyl(oxy); R<3> and R<4> are linked to form alkylene]. EXAMPLE:A 7-bis(sec-butoxycarbonyl)methylene-2,4-dioxa-6,8-dithia-3-methylbicycl o[3,3,0]octane. USE:An activator for liver function, and a remedy for hepatic diseases. PREPARATION:A compound shown by the formula III is reacted with a carbonyl compound shown by the formula IV preferably in an inert organic solvent such as benzene, etc. in the presence of an acid such as p-toluenesulfonic acid.
申请公布号 JPS60199892(A) 申请公布日期 1985.10.09
申请号 JP19840056436 申请日期 1984.03.24
申请人 NIPPON NOYAKU KK 发明人 NAGAMINE MASASHI;YANAKA KUNIAKI;KONAKA SHIGEO;NAKAYAMA KEISUKE;UCHIDA MATAZAEMON
分类号 C07D495/04;A61K31/385;A61P1/16 主分类号 C07D495/04
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