Pyrazolo¬4,3-d pyrimidine derivative process for its production antihyperlipidemic agent containing it, its intermediate, and process for the production of the intermediate

摘要

A pyrazolo[4,3-d]pyrimidine derivative having the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="27" wi="31" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sup>1</Sup> is lower alkyl, phenyl or substituted phenyl, R<Sup>2</Sup> is -A-CO<Sub>2</Sub>R<Sup>21</Sup> (wherein A is alkylene having from 1 to 3 carbon atoms which is unsubstituted or substituted by methyl, and R<Sup>21</Sup> is lower alkyl having from 1 to 4 carbon atoms), -CH<Sub>2</Sub>CO-phenyl, a saturated or unsaturated, straight chain or branched aliphatic group having from 3 to 16 carbon atoms, phenyl-lower alkyl, -CH<Sub>2</Sub>CN, substituted phenyl-lower alkyl, cyclohexylcyclohexyl, methylcyclohexyl, 4-thia-n-heptyl, 3,6-dioxa-n-octyl, 4-oxo-n-pentyl or
<Chemistry id="chema02" num="0002"><Image id="ia02" he="24" wi="29" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>(wherein R<Sup>22</Sup> is hydrogen or lower alkyl), and R<Sup>3</Sup> is a saturated or unsaturated, straight chain or branched aliphatic group having from 2 to 22 carbon atoms, phenyl-lower alkyl, substituted phenyl-lower alkyl, substituted or unsubstituted phenyl-methyloxyethyl or 2-hydroxyethyl.