| 摘要 |
NEW MATERIAL:The compound of formula I [R is (substituted) cyclic amino except for 3-substituted-1-piperazinyl; X is halogen]. EXAMPLE:1-Cyclopropyl-6-fluoro-7-( 1-piperazinyl )-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. USE:An antibacterial agent having high fat-solubility and exhibiting excellent peroral absorbability. PREPARATION:The 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3- carboxylic acid of formula II is made to react with the cyclic amine of formula RH (e.g. piperazine) in a solvent such as pyridine at 60 deg.C for 30min.
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