| 摘要 |
<p>Vaccine compsns. contg. inactivated or attenuated virus and a stabiliser consisting of, by wt. 2.5 pts. partially hydrolysed gelatine, 2-55 pts. of a polyhydroxyl alcohol of 6C, 0.5-1.7 pts. of a cell culture medium, and physiologically acceptable buffer sufficient to adjust the pH to 6-6.5 are new. The vaccines may be for measles, mumps, German measles, chicken pox, polio, hepatitis herpes simlex 1, herpes simplex 2 or mixtures of these. Greater stability than conventional vaccine mixtures. is achieved. A typical vaccine comps. contains measles virus and stabiliser prepd. from 35.7g partially hydrolysed gelatin 35.7g, partially hydrolysed gelatin, 35.7 sorbitol, 11.06gMedium 199 (Morgan etcoll. Proc. Sec. Exp. Biol & Med 73:1-8, 1950), 100 ml 1M sodium phosphate buffer pH 6.0 and distilled water to 1 litre. The vaccine also contained neomycin to prevent microbial growth, and was sealed in glass ampoules. This vaccine was stable after 4 months at 2-8 degrees C, whilst a similar vaccine contg. commercial stabiliser was not.</p> |
