| 摘要 |
PURPOSE:To produce the titled compound useful as an antispasmodic agent, etc. with simple operation, in high yield and purity, by reacting a piperidylidenemethane quaternary salt with a metal hydroxide, and reacting the resultant novel intermediate with a hydrohalogenic acid. CONSTITUTION:The novel piperidylidenemethane quaternary salt of formula IIcan be produced by reacting the piperidylidenemethane quaternary salt of formula I (R<1> is H or lower alkyl; R<2> and R<3> are lower alkyl; X is halogen or acid residue of an inorganic acid or organic acid alkyl ester) with a metal hydroxide (e.g. lithium hydroxide) or ammonium hydroxide. The obtained salt is made to react with a hydrohalogenic acid (e.g. HCl, HBr, etc.) to obtain a piperidylidenemethane quaternary salt of formula III (Y is halogen other than X). The use of large excess alkali, and the complicated operations such as extraction, distillation, etc. after the completion of the reaction are unnecessary in the above process. |
