| 摘要 |
<p>NEW MATERIAL:The imidazoleamidoxime having cyclopentene ring and represented by the formula I (R1 and R2 are H or OH-protecting group; R3 is H or OH-protecting group) or its salt. EXAMPLE:5-Amino-1-( 2',3'-dihydroxy-4'-hydroxymethyl-4'-cyclopenten-1'-yl)-imidazole-4-car boxamidoxime. USE:It has the activity to inhibit the proliferation of L-5178Y cell, and is useful as a carcinostatic agent. The compound can be recyclized to neplanocin A by the reaction with ethyl orthoformate, etc., and is useful also as a synthetic raw material of <14>C-labeled compound, or a raw material for inducing to a cyclopentene nucleoside having a 2-substituted purine ring or a base other than purine. PREPARATION:The compound of formula I can be prepared by converting the compound of formula II to an N-oxide, and treating the resultant compound of formula III with an alkali.</p> |
