| 摘要 |
NEW MATERIAL:The FR-900462 substance having the following physical and chemical properties. Shape and color, pale yellow powder; elemental analysis (%), C 62.60, H 7.01, N 8.11; color reaction, positive to cerium sulfate reaction, iodine reaction, ninhydrin reaction and Dragendorff reaction, negative to palladium reaction; solubility, soluble in methanol and acetone, slightly soluble in ethanol and chloroform, insoluble in water and benzene; melting point, 178- 182 deg.C; specific rotation, [alpha]<23>D=+186 deg. (C:1.05, methanol); etc. USE:Antibacterial agent and antitumor agent. PREPARATION:For example, Elytrosporangium tashikiense No.7124 (FERM P- 7393) belonging to Elytrosporangium genus is cultured in a nutrient medium, the culture liquid is centrifuged to separate the mycelia. The product is extracted with acetone, etc., and purified by column chromatography, etc. to obtain the novel substance. |
