| 摘要 |
<p>The present invention provides a process for the substitution of an acylamino beta -lactam compound at the carbon atom carrying the acylamino group, which process comprises reacting the beta -lactam compound with an halogenating agent and a nucleophilic reagent; characterised in that the acylamino group has an acidic group on the carbon atom adjacent the carbonyl group. In particular the process of this invention comprises reacting a beta -lactam of partial structure (I): <CHEM> where X represents an acidic group; with an halogenating agent and a nucleophilic reagent.</p> |
