| 摘要 |
beta-Lactamase inhibitors which are 6-alpha- and 6-beta-(aminomethyl) and (1-aminoethyl)pencillanic acid 1,1-dioxides, said aminomethyl compounds optionally substituted on amino nitrogen with benzyl, hydroxybenzyl, picolyl or phenethyl; pharmaceutically-acceptable salts thereof; conventional esters thereof hydrolyzable in vivo; bis-methanediol esters thereof; or mixed methanediol esters with said beta-lactamase inhibitors and sulbactam. Pharmaceutical compositions thereof in combination with a conventional beta-lactam antibiotic, used in the treatment of bacterial infections; compounds useful as intermediates in the synthesis of said beta-lactamase inhibitors. Antibacterial bis-methanediol esters of said beta-lactamase inhibitors and ampicillin or amoxicillin, also used in the treatment of bacterial infections; and intermediates therefor. |
