| 摘要 |
PURPOSE:To obtain an aromatic alpha-keto acid useful as a synthetic raw material for aromatic alpha-amino acids, alpha-hydroxy acids, etc., easily in high yield without decarbonylation, by hydrolyzing an aromatic alpha-keto acid amide with an aqueous solution of an alkali. CONSTITUTION:One equivalent aromatic alpha-keto acid amide of the formula (R<1> is aromatic group such as aryl, pyridyl or thienyl; R<2> and R<3> are H or alkyl, and one thereof is alkyl or R<2> and R<3> together may form a ring), e.g. benzoyl-N,N- diethylformamide, easily obtained by reacting an aromatic halide with a primary or secondary amine and CO in the presence of a Pd catalyst is dissolved or suspended in preferably 10-50 equivalents aqueous solution of an alkali (earth) metal hydroxide, e.g. 0.5-3N NaOH, heated under vigorous agitation and hydrolyzed for 1-12hr to give the aimed compound, e.g. benzoylformic acid.
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