| 摘要 |
NEW MATERIAL:An N-acetylneuraminic acid derivative shown by the formula I (R<1> is H, or acetyl; R<2> is nucleotide residue; R<3> is carboxyl, or methoxycarbonyl). EXAMPLE:2',3'-Isopropylidene-5'-O-(4-N-acetyl-2,4-dideoxy-1-carboxyl-D -glycero- beta-D-galacto-octapyranosyl)uridine. USE:An inhibitor against metastasis of cancer. PREPARATION:Methyl-2-chloro-4,7,8,9-tetra-O-acecyl- beta -D-N-acetylneuraminate shown by the formula II is reacted with a compound shown by the formula R<2>- H in a molar ratio of preferably 1.2:1 in the presence of a catalyst (preferably mercuric bromide). The reaction product is optionally hydrolyzed, it is isolated by rechromatography method, and purified.
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