| 摘要 |
PURPOSE:To produce the titled fluorine-containing steroid compound useful as an anti-inflammatory agent, in high yield, by reacting an alkali metal salt of an organic acid with fluorine gas, reacting the product with DELTA<3.5>-pregnadiene derivative, and separating the objective product from the reaction product. CONSTITUTION:An organic acid alkali metal salt (e.g. CH3COONa) is made to react with fluorine gas (usually diluted to <=20mol% with an inert gas such as N2) preferably in a chlorofluorocarbon solvent at about -75 deg.C. The obtained reaction mixture is made to react with a DELTA<3.5>-pregnadiene derivative, and the objective compound is separated from the product by column chromatography, high-performance liquid chromatography, etc.
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