COMPOSITION USEFUL FOR OBTAINING VACCINES CONTAINING PARTICLES CARRYING THE SURFACE ANTIGENE OF HEPATITIS B VIRUS & THE RECEPTOR OF POLYMERIZED HUMAN SERUM ALBUMIN
摘要
Composition useful for producing vaccines containing particles having immunogenic properties characteristic of antigen HBsAg, said particles being more particularly characterized in that they also contain a receptor for polymerized human albumin. They are obtained by transformation of human or animal cells by a vector containing a DNA sequence coding for the S and pre-S regions of a gene of viral hepatitis B, said DNA sequence being placed under direct control of a promoter enabling the efficient transcription of said sequence in human or animal cells transformable by said vector.
申请公布号
AU4061085(A)
申请公布日期
1985.09.24
申请号
AU19850040610
申请日期
1985.03.07
申请人
GROUPEMENT DE GENIE GENETIQUE, INSTITUT PASTEUR, INSTITUT;NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, CENTRE;NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人
SOBCZAK, ELIANE;MALPIECE, YVES;MICHEL, MARIE-LOUISE;TIOLLAIS, PIERRE;STREECK, ROLF E.