| 摘要 |
Compounds of formula (1> <IMAGE> and their pharmaceutically acceptable acid addition, alkali metal, and alkaline earth metal salts, wherein Q is Y1-C(O)-@H(R4)-NH-, -NH2, R5-C(O)-S(C*H R4)n-, or HS-(C*H R4)n-; Y1 and Y2 are independently -OH, -OR, or -NR1R2; Z is -O-, -S-, -N(R)-, or -S(O)-; n is zero or one; R, R1, R2, R3, R4 and R5 are independently hydrogen, C1-8 alkyl, C6-12 aryl, aryl-alkyl (wherein aryl is C6-10 and alkyl is C1-6), C3-10 cycloalkyl, fused C8-12 cycloalkylaryl, heterocyclic, or C1-6alkyl group which is substituted with -NH2, -NH-C(NH2)=NH, or -N-C=NCH=CHCH=N; or R4 can be G'-(CH2)1-6-X1-(CH2)1-6- wherein G' is C6-12 aryl or fused C8-12 arylcycloalkyl, and -X1- is -S-, -O-,-NH-, or -S(O)-; X is a C1-3 alkylene bridge which is optionally substituted with hydroxy, phenyl, C1-C6 alkyl, or C1-C6 alkoxy; A1 and A2 are independently halogen, -OH, -OR, -CF3, -NR1R, -C(O)Y1, -SO2R, or -SO2NR1R, or A2 is also hydrogen; wherein the alkyl, cycloalkyl, aryl and fused aryl-cycloalkyl groups may be further substituted are useful in the treatment of hypertension and congestive heart failure. |
