发明名称 |
PEPTIDE RENIN INHIBITORS CONTAINING STATINE OR DERIVATIVES THEREOF 0 |
摘要 |
A series of novel peptide and polypeptide derivatives containing statine or derivatives thereof (e.g., aminostatine, cyclostatine) are disclosed that are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Of particular interest are compounds possessing the N-terminal sequence -Pro-Phe-His-Sta-Lys with the terminal proline nitrogen bonded to an amino-protecting acyl moiety or compounds possessing the N-terminal sequence -R-Phe-His-Sta-Lys- wherein R represents an amino protecting acyl group. |
申请公布号 |
AU3974485(A) |
申请公布日期 |
1985.09.19 |
申请号 |
AU19850039744 |
申请日期 |
1985.03.12 |
申请人 |
PFIZER INC. |
发明人 |
JASJIT SINGH BINDRA;EDWARD FOX KLEINMAN;ROBERT LOUIS ROSATI |
分类号 |
C07K14/81;A61K38/00;A61K38/55;A61P9/12;A61P43/00;C07K5/02 |
主分类号 |
C07K14/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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