Alpha-1-antitrypsin mutants and DNA coding therefor and the production of each, and therapeutic formulations using such mutants and their preparation.

摘要

Methods and DNA constructs are provided for producing site specific mutagenized alpha-1-antitrypsin.
<??>Particular mutants are formed having a mutation in the active site of alpha-1-antitrypsin at amino acid position 358 and at amino acid position 342. Such mutants are therapeutically useful.