PROCEDIMIENTO DE OBTENCION DE 2, 6-DIMETIL-4-(3'-NITROFENIL)-1, 4-DIHIDROPIRIDIN-3, 5-DICARBOXILATO DE 2-N-PROPOXIETILO

摘要

The 2-n-propoxyethyl ester of 2,6-dimethyl 4-(3'-nitrophenyl) 1,4-dihydro pyridine 3,5-dicarboxylic acid is made by reaction of the 2-n-propoxyethyl ester of 2-(3'-nitro benzylidene) acetoacetic acid with 2-n-propoxyethyl beta-amino croton ate in non-hydroxylic solvent in presence of a dehydrating agent e.g. dicyclohexyl carbo-imide, at between ambient temp. and b.pt. for 1-20h. to give the prod. of formula (I). This is purified by pption. and crystallisation or column chromatography.