| 摘要 |
NEW MATERIAL:The compound of formula 8 [R<1> is (substituted) aliphatic or aromatic group; R<2> is C(=O)SR<4> (R<4> is same as R<1>) or -CF2SR<4>; R<3> is H or same as R<1>]. USE:Useful as a synthetic intermediate of a fluorine-containing organic compound such as beta-fluoroallyl alcohol, a heterocyclic compound, etc. PREPARATION:The compound of e.g. formula 6 can be prepared by (1) converting the compound of formula 1 prepared by conventional method to the addition product of formula 3, (2) dehydrofluorinating the addition product to the ketone of formula 4 simultaneously to the step (1), (3) reacting the ketone with a Grignard reagent, and (4) heating the resultant carbinol of formula 5 at 100- 200 deg.C.
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