| 摘要 |
PURPOSE:To obtain the titled compound useful as a raw material of acetoacetic acid 3-nitratopropyl ester which is a synthetic raw material of a compound useful as a remedy for circulatory diseaes, economically, by reducing a 3-nitratopropionic acid lower alkyl ester with an inexpensive reducing agent. CONSTITUTION:The titled compound can be produced by reducing 3-nitrato- propionic acid lower alkyl ester in an inert solvent with a borohydride or aluminum hydride reducing agent. The temperature of the reaction is 20-120 deg.C for borohydride-type reducing agent, and -50-+30 deg.C for aluminum hydride-type reducing agent. The most preferable reducing agent is NaBH4-CaCl2, and the most preferable 3-nitratopropionic acid lower alkyl ester is methyl 3-nitratopropionate. The inert solvent is e.g. methanol, dimethoxyethane, etc. for the borohydride-type agent and ether, etc. for the aluminum hydride-type agent.
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