| 摘要 |
<p>PURPOSE:To obtain the titled compound useful as an intermediate for penem, carbapenem derivatives (antimicrobial agents), etc. easily in very high yield with retained optical activity of raw materials, by reacting 3-mercaptopyrrolidine having an amino protecting group into contact with an acid. CONSTITUTION:A compound expressed by the formula (R is a protecting group of amino group) is brought into contact with an acid, e.g. a hydrogen halide such as hydrogen chloride, hydrogen bromide or hydrogen fluoride, an organic sulfonic acid such as methanesulfonic, ethanesulfonic, phenylsulfonic acid or toluenesulfonic acid, an organic acid such as mono- - trichloroacetic acid or trifluoroacetic acid or a mineral acid such as sulfuric, nitric or perchlonic acid usually at 0-40 deg.C, preferably 10 deg.C- about room temperature usually for 0.5- 5hr to give advantageously 3-mercaptopyrrolidine or a salt thereof.</p> |
