发明名称 |
(Bis(substituted methyl)-methyl)-isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them. |
摘要 |
<p>The subject-matter of the invention are new Äbis(substituted methyl)-methylÜ-isoquinoline derivatives of the formula (I) <CHEM> wherein R<1> and R<2> represent hydroxyl or alkoxy having from 1 to 6 carbon atoms, R<3> is hydrogen, aralkyl having from 1 to 4 carbon atoms in the alkyl moiety or a - @ - R<4> group, in which R<4> is alkyl having from 1 to 5 carbon atoms or phenyl, optionally substituted, preferably by one or more alkyl having from 1 to 4 carbon atoms, alkoxy having from 1 to 4 carbon atoms, halogen and/or nitro, or is -NH-phenyl, X is oxygen or sulfur, R<7> is hydroxyl, halogen or an - O - @ - R<9> group, R<8> is halogen, alkoxy having from 1 to 4 carbon atoms or an - O - @ - R<9> group, in which X has the same meaning as defined above and R<9> independently from R<4> may have the same meanings as defined for R<4>, or is an -NH(C1-4-alkyl) or C3-6-cycloalkyl group, and salts thereof as well as a process for preparing these compounds and pharmaceutical compositions containing them.</p> |
申请公布号 |
EP0153994(A1) |
申请公布日期 |
1985.09.11 |
申请号 |
EP19840112854 |
申请日期 |
1984.10.25 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR R.T. |
发明人 |
BERNATH, GABOR, DR. DIPL.-CHEM.;KOBOR, JENO, DR.;FULOP, FERENC, DR. DIPL.-CHEM.;MOTIKA, GABOR, DR. DIPL.-CHEM.;SOHAJDA, ATTILA, DIPL.-PHARM.;EZER, ELEMER, DIPL.-CHEM.;HAJOS, GYORGY, DR. DIPL.-PHARM.;PALOSI, EVA, DR.;DENES, LASZLO, DR. DIPL.-PHARM.;SZPORNY, LASZLO, DR. |
分类号 |
A61P25/24;A61K31/47;A61K31/472;A61P1/04;A61P9/00;A61P25/04;A61P25/26;A61P29/00;A61P37/06;C07D217/14;C07D217/16;(IPC1-7):C07D217/14 |
主分类号 |
A61P25/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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