发明名称 |
Process for the preparation of a free L alpha -amino acid |
摘要 |
This invention relates to a process for the preparation of free L alpha -amino acids by the complete conversion of their D antipodes taken individually or possibly in racemic mixtures. The process according to the present invention is characterized in that the D antipodes of an ester of said alpha -amino acid is racemized in the presence of a chemical catalyst formed by at least one aromatic aldehyde corresponding to the general formula: <IMAGE> (I) wherein: Ar represents an aromatic ring optionally containing a heteroatom, such as nitrogen, and B represents a basic function, to produce a mixture in dynamic equilibrium of the two forms D and L of said ester, the ester which is present in the L form is hydrolyzed enzymatically and irreversibly to produce the corresponding stereostable L alpha -amino acid, said stages of chemical racemization and of enzymatic hydrolysis being carried out under identical reaction conditions, and the free L alpha -amino acid is recovered.
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申请公布号 |
US4540792(A) |
申请公布日期 |
1985.09.10 |
申请号 |
US19830472479 |
申请日期 |
1983.03.07 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSTITUT NATIONAL DE LA SANTE ET DE LA RESERCHE MEDICALE |
发明人 |
COMMEYRAS, AUGUSTE;PREVIERO, ALDO;PUGNIERE, MARTINE |
分类号 |
C12P13/04;C07C67/00;C07C227/00;C07C227/16;C07C227/18;C07C227/36;C07C229/02;C07D213/48;C12P41/00;(IPC1-7):C07D233/64;C07D209/20;C07D207/16 |
主分类号 |
C12P13/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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