| 摘要 |
NEW MATERIAL:A benzothiazepine derivative shown by the formula (R<1> is 5- 20C straight-chain or branched long-chain higher alkyl; one or both of R2 and R3 are hydroxyl group or lower alkoxy), its various isomers and its various salts. EXAMPLE:5-t-Butoxycarbonylmethyl-3-( L )-( 1-carboxyhexylamino-2, 3-dihydro-1,5- benzothiazepin-4(5H)-one. USE:Having very high inhibitory actions on an enzyme capable of converting angiotensin and pharmaceutical characteristics such as antihypertensive action, etc., useful as a remedy for hypertension, and a remedy for a circulatory disease. PREPARATION:For example, a compound shown by the formula II and a compound shown by the formula III are dissolved in a proper solvent such as water, methanol, etc., processed into a corresponding Schiff base, and reduced with a proper reducing agent, to give a compound shown by the formula I .
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