| 摘要 |
PURPOSE:To obtain the titled substance useful as a sweetener with low calorie industrially advantageously, by hydrolyzing partially benzyl-carboxymethyl- diketopiperazine with a strong acid in a mixed solvent consisting of methanol and water. CONSTITUTION:3-Benzyl-6-carboxymethyl-2,5-diketopiperazine(alpha-AP.DKP for short) is partially hydrolyzed with a strong acid preferably hydrohalogenic acid such as hydrochloric acid, etc.) in a mixed solvent of methanol and water (in a molar ratio of preferably 0.01-1.0) at 20-80 deg.C, to give the desired compound. The concentration of the strong acid is preferably <=10M/l.
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