| 摘要 |
NEW MATERIAL:The compound of formula I (R<1> is lower alkyl; R<2> is lower alkyl or H; Y is hydroxymethylene, lower alkoxymethylene, aminomethylene, hydroxyiminomethylene, carbonyl, etc.) and its pharmacologically permissible salt. EXAMPLE:alpha-Methyl-4-(alpha-hydroxy-3-pyridylmethyl)cinnamic acid ethyl ester. USE:Preventive and remedy for various thrombosis. PREPARATION:For example, the compound of formula I wherein Y is hydroxymethylene can be produced by reacting the compound of formula II with the compound of formula III (R<3> is lower alkyl; M is phenyl) in a solvent such as chloroform, THF, etc. at 10-20 deg.C.
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