7-OXO-4-TIA-1-AZABICYKLO/3,2,0/ HEPT-2-ENDERIVAT.

摘要

A compound of formula I (I) with R1 being an alkyl group substituted by one or more substituents and esters thereof at the 2-carboxy group or at the 8-hydroxy group or both; and salts thereof. Compounds I have antibacterial effect. Various intermediates are described. This compound of the formula I, or an ester at the 2-carboxy group or at the 8-hydroxy group or both or a salt thereof is produced by reacting a compound of formula II or of formula IX II IX in which R represents a hydrogen atom or a carboxy protecting group, R3 represents an activated carboxylic acid group, R4 represents an alkyl group having 1 to 4 carbon atoms, or a phenyl group which may be unsubstituted or substituted, R15 represents a phenyl group or an alkyl group having from 1 to 4 carbon atoms, and X represents an oxygen or sulphur with an amine of the formula III R1NH2 (III) to give a compound of formula I, or an ester thereof of formula Ia (Ia)