| 摘要 |
NEW MATERIAL:The basic polypeptide having an immunity interferon-like activity, composed of 131-132 amino acid residues, and having the following characteristics. Apparent molecular weight, 16,000 (17,000 by HLC molecular sieve process); isoelectric point (PI value), 9.2-10; amino acid terminal, cysteine or methionine; COOH terminal, lysine; amino acid composition, Asy 20, Thr 5, Ser 9, Glx 16, Pro 2, Gly 4, Ala 7, Cys 2, Val 8, Met 3-4, Ile 7, Leu 9, Tyr 5, Phe 9, Lys 19, His 2, Arg 3, and Trp 1. USE:Antiviral agent, antitumor agent, and immunoregulator. PREPARATION:The objective polypeptide can be produced by culturing a microbial strain transformed with a plasmid containing a chemically synthesized DNA sequence coding the amino acid sequence of formula.
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