| 摘要 |
Norborane derivatives of the formula: <CHEM> wherein substituents A, B, X and Y each are independently selected from hydrogen, hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms), methylenephosphonic, methylene-, ethylene- and propylene-sulfonic, alkyl carboxylic acid radicals (having 2-4 carbon atoms) and the alkali or alkaline earth metal, ammonium and amine salts of any of the phosphoric, sulfonic or carboxylic acid derivatives, and wherein at least one of A, B, X and Y is other than a hydrogen, are sequestering and/or chelating agents. These derivatives are also useful as complexing agents for radionuclides for imaging the skeletal system in animals. The derivatives containing at least one methylenephosphonic acid radical or a salt thereof are also useful as threshold agents to prevent metal ion precipitation in aqueous solutions. |
