| 摘要 |
3-Q-4-R2-5-(2-Q'-5-R3-4-thiazolyl)-6-R1-2(1H)-pyridinones (I), where R1 is alkyl having from one to four carbon atoms, R2 is hydrogen or methyl, R3 is hydrogen or alkyl having from one to three carbon atoms, Q is amino, carbamyl, carboxy, cyano or hydrogen, and Q' is alkyl having from one to four carbon atoms, amino or R4NH where R4 is alkyl having from one to four carbon atoms, or acid-addition salts thereof where at least one of Q and Q' is amino or Q' is R4NH, are useful as cardiotonics (I where Q is amino, cyano or hydrogen) and/or as intermediates (I where Q is cyano, carbamyl or carboxy). Also shown as intermediates are 1,2-dihydro-4-R2-5-[R3CH(Br)CO]-6-R1-2-oxo-3-pyridinecarbonitriles (II), and, also, processes for preparing I and II.
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